Production and/or coating granules, of e.g. pharmaceutical products, involves vaporizing organic solvent, and using heated fluidized bed gas to produce fluidized bed and fluidized bed waste gas as fluidized bed gas

摘要

Granules in fluidized bed are produced and/or coated by vaporizing organic solvent contained in the medium, and using heated fluidized bed gas containing organic solvent, to produce the fluidized bed and fluidized bed waste gas as fluidized bed gas after partial condensation of the solvent and re-heating of the obtained gas. Production or coating granules in fluidized bed comprises applying a liquid medium containing a granule and/or coating-forming compound, or reaction component by spraying to particles in the fluidized bed and having a smaller mean diameter than that of the particles to be produced. An organic solvent contained in the medium is vaporized. A heated fluidized bed gas containing organic solvent is used to produce the fluidized bed and the fluidized bed waste gas is used as fluidized bed gas after partial condensation of the solvent and re-heating of the gas so obtained. An Independent claim is also included for an apparatus for producing or coating of granules in fluidized bed, comprising a fluidized reactor (1) having in-flow base (2) and spray nozzle (3), solid/gas separating device (4), fluidized bed gas heating device (5), and granule-discharging device (7). The apparatus further comprises condensation device (8) and circulating pipe (9).