5'-CARBAMOYL-1,1-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS

摘要

Compounds of formula (I): wherein when m is 0 to 4 R1 is selected from C1−6alkyl, C3−7cycloalkyl, C2−6alkenyl, −SO2NR4R5, −CONR4R5 and −COOR4; and when m is 2 to 4 R1 is additionally selected from C1−6alkoxy, hydroxy, NR4R5, −NR4SO2R5, −NR4SOR5, −NR4COR5, and −NR4CONR4R5; R2 is selected from hydrogen, C1−6alkyl and −(CH2)n−C3−7cyc loalkyl; R3 is the group −CO−NH−(CH2)p−R6; U is selected from methyl and halogen; W is selected from methyl and chlorine; V and Y are each selected independently from hydrogen, methyl and halogen; m is selected from 0, 1, 2, 3 and 4 wherein each carbon atom of the resulting carbon chain may be optionally substituted with one or two groups selected independently from C1−6alkyl; n is selected from 0, 1, 2 and 3; p and r are independently selected from 0, 1 and 2; s is selected from 0, 1 and 2; or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.