METHOD OF SCREENING CELL DEATH INHIBITOR

摘要

It is intended to provide a method of screening a substance which inhibits cell death induced by the activation of PAPR, in particular, a substance whi ch is useful as a remedy and/or a preventive for rheumatoid arthritis, nerve ce ll death in brain ischemia, heart cell death after arteriosclerosis reperfusion , autoimmune disruption of pancreatic islet b-cells, cell death following shoc k or inflammatory reaction due to immune cell death. Also, novel proteins and novel genes encoding the same are provided. The above screening method involves the step of bringing a test substance into contact with cells expressing LTRPC2 protein under conditions allowing the activation of the LTRPC2 protein, and the step of analyzing the inhibition of the activation o f the LTRPC2 protein. The above-described novel proteins are rat and mouse LTRPC2 proteins, while the above novel genes are rat and mouse LTRPC2 genes.