发明名称 |
Novel substituted succinic acid metallo-beta-lactamase inhibitors and their use in treating bacterial infections |
摘要 |
This invention relates to novel substituted succinic acid metallo-beta-lactamase inhibitors which are useful potentiators of beta-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections in animals or humans which comprises administering, together with a b-lactam antibiotic, a therapeutically effective amount of a compound of formula I: including pharmaceutically acceptable salts, prodrugs, anhydrides, and solvates thereof.
|
申请公布号 |
US2003078418(A1) |
申请公布日期 |
2003.04.24 |
申请号 |
US20020099790 |
申请日期 |
2002.03.15 |
申请人 |
BALKOVEC JAMES M.;GREENLEE MARK L.;OLSON STEVEN H.;ROUEN GREGORY P. |
发明人 |
BALKOVEC JAMES M.;GREENLEE MARK L.;OLSON STEVEN H.;ROUEN GREGORY P. |
分类号 |
C07D233/60;A61K31/194;A61K31/407;A61K31/4164;A61K31/4985;A61K45/00;A61P31/04;A61P43/00;C07C57/38;C07C57/58;C07C59/64;C07C69/612;C07C69/734;C07C229/34;C07C257/14;C07C271/22;C07C279/14;C07D307/91;C07D333/20;C07D405/06;C07D409/06;C07D487/18;C07D521/00;(IPC1-7):C07D279/12;C07D265/30;C07D241/04 |
主分类号 |
C07D233/60 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|