发明名称 |
PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use |
摘要 |
The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NB-ARC domains and LRR domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that alter an association of a PAAD domain-containing polypeptides. Further provided are methods of identifying agents that modulate PAAD domain-mediated inhibition of NFkappaB activity, or modulate an activity of an NB-ARC domain of a PAAD domain-containing polypeptide. Also provided are methods of modulating NFkappaB transcriptional activity in a cell, and methods of altering expression of a PAAD domain-containing polypeptide in a cell.
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申请公布号 |
US2003077699(A1) |
申请公布日期 |
2003.04.24 |
申请号 |
US20010965621 |
申请日期 |
2001.09.25 |
申请人 |
REED JOHN C.;GODZIK ADAM;CHU ZHI-LIANG;PAWLOWSKI KRZYSZTOF;FIORENTINO LOREDANA;ARIZA MARIA EUGENIA;STEHLIK CHRISTIAN |
发明人 |
REED JOHN C.;GODZIK ADAM;CHU ZHI-LIANG;PAWLOWSKI KRZYSZTOF;FIORENTINO LOREDANA;ARIZA MARIA EUGENIA;STEHLIK CHRISTIAN |
分类号 |
A61K38/00;C07K14/47;(IPC1-7):G01N33/53;C12P21/02;C12N5/06;C07H21/04;C07K14/705 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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