METABOLIC CONTROLLED FERMENTATION PROCESS FOR PSEUDOMONIC ACID PRODUCTION
摘要
An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a submerged medium at a temperature within about 20- 5 30°C. The pH of the fermentation medium is regulated to be at about 5.5-6.0 by feeding the fermentation medium with an assimilable carbon source, a mineral salt, or an acidic/alkali solution. Accordingly, the resulting fermentation broth contains an increased yield of highly purified pseudomonic acid A as the main component. The pseudomonic acid B as an impurity in the fermentation broth is significantly decreased.
申请公布号
WO03000910(A3)
申请公布日期
2003.04.24
申请号
WO2002US20044
申请日期
2002.06.21
申请人
BIOGAL GYOGYSZERGYAR RT;TEVA PHARMACEUTICALS USA, INC.;GULYAS, EVA;BALOGH, GABOR;ERDEI, JANOS;SERESS, PETER
发明人
GULYAS, EVA;BALOGH, GABOR;ERDEI, JANOS;SERESS, PETER