HIGH-CONCENTRATION PROTEIN FORMULATIONS AND METHOD OF MANUFACTURE
摘要
Provided is a pharmaceutical composition involving a concentrated mixture of a precipitated protein and a liquid medium and a method for manufacturing the concentrated mixture. The concentrated mixture is manufacturable by precipitation of a protein with a biocompatible polymer precipitating agent, followed by removal of sufficient liquid to concentrate the resulting mixture to the desired degree. The precipitated protein can be stored for a significant time in the concentrated mixture, such as intermediate between processing stages during manufacture operations.
申请公布号
WO03032907(A2)
申请公布日期
2003.04.24
申请号
WO2002US32872
申请日期
2002.10.16
申请人
RXKINETIX, INC.;UNIVERSITY LICENSE EQUITY HOLDINGS, INC.
发明人
ETTER, JEFFREY, B.;SAMANIEGO, ADRIAN, C.;CARPENTER, JOHN, F.