| 发明名称 |
CARBOXYLIC ACID DERIVATIVE INHIBITING BINDING OF INTEGRIN TO RECEPTOR |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for inhibition of binding ofα4β1 integrin to its receptor, e.g. vascular cell adhesion molecule-1 (VCAM-1) and fibronectin, a compound inhibiting the binding and a pharmaceutically active composition comprising the compound. SOLUTION: (3S)-[( [1-(2-Chlorobenzyl)-4-hydroxy-5-methyl-2-oxo-1,2- dihydropyridin-3-yl]amino}carbonyl)amino]-3-(4-methylphenyl)-propanoic acid derivative is used for control or prophylaxis of disease states in which theα4β1 is involved. |
| 申请公布号 |
JP2003119181(A) |
申请公布日期 |
2003.04.23 |
| 申请号 |
JP20020031953 |
申请日期 |
2002.02.08 |
| 申请人 |
TEXAS BIOTECHNOLOGY CORP |
发明人 |
BIEDIGER RONALD J;CHEN QI;SCOTT IAN L;MARKET ROBERT V;LI WEN;KASSIR JAMAL;HOLLAND GEORGE W;WU CHENGDE;DECKER RADFORD E;LI JIAN |
| 分类号 |
C07D221/04;A61K31/435;A61K31/44;A61K31/4412;A61K31/4704;A61K31/495;A61K31/50;A61K31/505;A61P1/00;A61P3/10;A61P9/10;A61P11/06;A61P19/02;A61P25/00;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P37/08;C07D207/416;C07D211/86;C07D213/02;C07D213/62;C07D213/69;C07D213/72;C07D213/75;C07D215/22;C07D215/38;C07D221/16;C07D237/16;C07D237/22;C07D239/28;C07D239/46;C07D239/47;C07D317/46;C07D317/60;C07D401/04;C07D401/12;C07D403/12;C07D405/12;C07D409/06;C07D409/12;C07D409/14;C07D413/04;C07D413/06;C07D413/12;C07D417/06;C07D471/04;C07D498/04;C07K14/78;(IPC1-7):C07D213/75 |
主分类号 |
C07D221/04 |
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