Process for producing liquid dosage formulations of medicinal compounds on demand from tablets and capsules using a mixing cup with an abrasive interior surface

摘要

The invention relates to a process and device for making liquid dosage formulations from solid dosage forms, and the pharmaceutical compositions produced therefrom. The solid dosage forms are tablets and capsules. The device comprises a single-use mixing and dosing cup having an abrasive interior surface and may include a mixing blade attached to an external motor. A liquid dosage formulation is prepared by combining a solid dosage form of a pharmaceutical medicament and an aqueous diluent in the mixing and dosing cup. The solid dosage form is rapidly broken down into its constituent particulates using agitation, disintegration and abrasion. The resultant liquid mixture is flavored and thickened to suit the needs of individual patients. The mixing and dosing cup is designed to allow for the administration of the liquid formulation directly to the patient.