N-hydroxacylamino compounds, process for their preparation and pharmaceutical compositions containing them

摘要

A compound of the formula (I):wherein:R1 is C1-6alkyl, aryl or arylC1-6alkyl;R2 is hydrogen, C1-6alkyl, C3-8cycloalkyl, aryl or arylC1-6alkyl;R3 is hydrogen, C1-6alkyl or arylC1-6alkyl; or R2 and R3, together with the carbon atom to which they are joined, form a C3-8cycloalkyl ring;R4 is benzyl, phenethyl, phenylpropyl, phenylbutyl or flurophenylbutyl;R5 is hydrogen, C1-6alkyl or arylC1-6alkyl;R6 is hydrogen, C1-6alkyl, C2-6alkenyl, C3-8cycloalkylC1-6alkyl, arylC1-6alkyl, heteroarylC1-6alkyl or the side-chain of a naturally occurring amino acid;R7 is hydrogen or C1-6alkyl;R8 is hydrogen, C1-6alkyl, C3-8cycloalkyl, C3-8cycloalkenyl, arylC1-6alkyl, heteroarylC1-6alkyl or heterocyclylC1-6alkyl;R9 is hydrogen or C1-6alkyl;or R8 and R9, together with the nitrogen atom to which they are joined, form a heterocyclic ring;wherein any group or ring in R1-R9 is optionally substituted;or a pharmaceutically-acceptable salt or in vivo hydrolysable precursor thereof.