发明名称 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
摘要 |
The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formulawhereinW represents -C(=O)- or -CH(OH)-;R1 represents hydrogen or hydroxy;R2 represents hydrogen;R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;n is an integer of from 1 to 5;m is an integer 0 or 1;R3 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; andpharmaceutically acceptable salts and individual optical isomers thereof,with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearingR1 and R2 or where R1represented hydroxy, n is an integer 0.
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申请公布号 |
US6552200(B2) |
申请公布日期 |
2003.04.22 |
申请号 |
US20000725259 |
申请日期 |
2000.11.29 |
申请人 |
MERRELL PHARMACEUTICALS INC. |
发明人 |
KRAUSS RICHARD C.;STROM ROBERT M.;SCORTICHINI CAREY L.;KRUPER WILLIAM J.;WOLF RICHARD A.;WU WEISHI W.;CARR ALBERT A.;HAY DAVID A.;RUDISILL DUANE E.;PANZONE GIANBATTISTA |
分类号 |
C07D295/18;A61K;A61K31/445;A61P11/08;A61P37/00;A61P37/08;A61P43/00;C07C33/46;C07C39/24;C07C45/46;C07C45/63;C07C45/65;C07C45/67;C07C47/273;C07C49/792;C07C49/798;C07C49/80;C07C49/813;C07C49/82;C07C49/825;C07C49/83;C07C49/835;C07C49/86;C07C59/86;C07C59/88;C07C59/90;C07C69/007;C07C69/16;C07C69/612;C07C69/65;C07C69/738;C07C69/78;C07C235/34;C07C235/78;C07C235/84;C07C255/16;C07C255/36;C07C255/40;C07C257/06;C07C259/06;C07D;C07D211/08;C07D211/14;C07D211/16;C07D211/22;C07D211/34;C07D211/44;C07D211/46;C07D295/16;C07D295/185;C07D401/06;C07D401/10;C07D491/107;(IPC1-7):C07D211/22 |
主分类号 |
C07D295/18 |
代理机构 |
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地址 |
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