METHOD FOR DETECTION OF INHIBITING ACTION OF SUBSTANCES UPON COMPLEMENT IN VIVO IN MODEL ANIMALS

摘要

FIELD: medicinal immunology. SUBSTANCE: mice are intravenously injected (into retroorbital venous plexus) with mink's serum at quantity of below 0.1 ml/mouse that leads to murine death. To study the action of inhibiting agent the latter is introduced simultaneously with mink's serum or 2 min before its injection. Its efficiency is determined by that its minimal introduced quantity which eliminates animal's death. The present innovation widens the number of techniques used in studying immune system in mammalians. EFFECT: higher efficiency. 1 ex, 1 tbl