BIOCONJUGATIVE COMPLEXES, METHOD OF THEIR SYNTHESIS (VARIANTS), PHENYLBORATE COMPLEX- -FORMING CROSS-LINKING REAGENTS, KIT OF AGENTS OR SYSTEM, METHOD OF ISOLATION OF REQUIRED CELL POPULATION

摘要

FIELD: organic chemistry, cellular biology. SUBSTANCE: invention relates to group of novel bioconjugative complexes of the general formula a: BAS-L-Bc-L'-(Bc'-L'')n-BAS' where BAS, BAS', BAS'' are bioactive components that can be both similar and different; Bc and Bc' are complexes of phenylboric acid; L, L', L'' are linkers; n = 0 or 1. Invention relates also to three methods of their synthesis, intermediate substances used in their synthesis and representing complexforming reagents and phenylborate cross-linked reagents, method of isolation of required cells population and also to kit or system containing bioconjugate A for isolation of required cells population. EFFECT: improved methods of synthesis and isolation. 9 cl, 26 ex