MICROBES HAVING AN ATTENUATING MUTATION COMPRISING A TRANSCRIPTION TERMINATOR

摘要

Compositions comprising a microbe having an attenuating mutation comprising a recombinant transcription terminator insertion in a chromosomal gene are disclosed. The compositions can be used as vaccines or carrier vehicles for delivering a desired protein to an individual. Also disclosed are methods fo r immunizing an individual and methods of delivering a desired gene product to an individual based upon administration of the compositions.