| 摘要 |
Pyrrole derivatives represented by the following formula: <CHEM> wherein Ring Z is an optionally substituted pyrrole ring, etc.; W<2> is -CO-, -SO2-, an optionally substituted C1-C4 alkylene, etc.; Ar<2> is an optionally substituted aryl, etc.; W<2> and Ar<1> mean the following (1) and (2): (1) W<1> is an optionally substituted C1-C4 alkylene, etc.; Ar<1> is an optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W<1> is an optionally substituted C2-C5 alkylene, an optionally substituted C2-C5 alkenylene, etc.; and Ar<1> is an aryl or monocyclic heteroaryl, which are substituted by carboxyl, an alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W<1>, or a pharmaceutically acceptable salt thereof These compounds are useful as medicaments such as a fibrosis inhibitor for organs or tissues.
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