METHOD FOR PRODUCING MESO-ZEAXANTHINE

摘要

PROBLEM TO BE SOLVED: To provide a method for efficiently producing a meso-zeaxanthine in a high yield. SOLUTION: This method for producing the three-dimensionally homogeneous meso-zeaxanthine comprises (a) resolving a racemic mixture of acetylenediols (R-I) and (S-I) to enantiomers (R-I) and (S-I), (b) each converting the enantiomers (R-I) and (S-I) to 15C phosphonium salts (R-II) and (S-II), (c) reacting R-II or S-II with a 10C dialkylmonoacetal by Wittig reaction to provide 25C acetal R-IV or S-IV, (d) converting R-IV or S-IV to 25C aldehyde R-V or S-V and (e) reacting R-V with a 15C phosphonium salt S-II or reacting S-V with a 15C phosphonium salt R-II.