New process to complex active materials with a solid support in order to improve water solubility, using a supercritical fluid

摘要

Process for the preparation of compounds formed by interaction of an active substance that is sparingly soluble in water with a porous support. Process for the preparation of compounds formed by interaction of an active substance that is sparingly soluble in water with a porous support, the process comprising: (1) mixing the active substance that has been generated using a supercritical fluid with the desired amount of porous support; (2) contacting the mixture in a static mode with a supercritical fluid and allowing molecular diffusion to take place for the time that is necessary to improve dissolution in an aqueous medium; (3) washing the compound formed with a flow of supercritical fluid, and; (4) recovering the interaction product thus formed.