Peptide beta-strand mimics based on 1,2-dihydro-3(6H)-pyridinone

摘要

Peptide analogs formed by replacing one or more, but not all, amino acids of a peptide chain with 1,2-dihydro-3(6H)-pyridinone, display an unusually strong tendency to assume a beta-strand conformation and to enter into beta-sheet-like interactions with peptides and other peptide analogs that engage in beta-sheet-like interactions with peptides. The peptide analogs of this invention therefore have utility has beta-strand mimics offering advantages over native peptides as well as beta-strand mimics of the prior art.