There is provided an assay for selecting an anti-viral agent effective against picornavirus infection. The assay selects ann agent which disrupts the association between picornavirus protein 2C and the host cell protein D-AKAP2, which association has been found to be essential for successful viral replication. Also disclosed are anti-viral agents having such properties and a method of combating picornavirus replication.
申请公布号
WO0248708(A3)
申请公布日期
2003.04.17
申请号
WO2001GB05487
申请日期
2001.12.12
申请人
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS;RYAN, MICHAEL;WILEMAN, TOM;KNOX, CAROLINE
