COMPOSITIONS COMPRISING HYDROXYAPATITE USEFUL FOR THE ADMINISTRATION OF THERAPEUTIC AGENTS
摘要
Compositions and methods for <i>in vivo</i> delivery of pharmaceutically active agents associated with hydroxyapatite (HAP). Compositions comprising a pharmacologically active agent and HAP in a pharmaceutically acceptable carrier, the composition providing controlled release of the pharmacologically active agent when introduced into the body. The pharmaceutically acceptable carrier can be a polymer paste or gel which may contain a second pharmacologically active agent. Methods of making and administering a controlled release compositions for the delivery of a pharmacologically active agent, such as a nucleic acid, in combination with a polycationic polymer and in a pharmaceutically acceptable carrier, to a mammal in a pharmaceutically effective amount.
申请公布号
WO03030943(A1)
申请公布日期
2003.04.17
申请号
WO2002CA01514
申请日期
2002.10.08
申请人
THE UNIVERSITY OF BRITISH COLUMBIA;ARC PHARMACEUTICALS, INC.;SPRINGATE, CHRIS;JACKSON, JOHN, K.;WONG, WESLEY;BURT, HELEN, M.
发明人
SPRINGATE, CHRIS;JACKSON, JOHN, K.;WONG, WESLEY;BURT, HELEN, M.