2- AND 4-AMINOPYRIMIDINES N-SUBSTTITUDED BY A BICYCLIC RING FOR USE AS KINASE INHIBITORS IN THE TREATMENT OF CANCER

摘要

A coumpound of the formula (I) wherein each X is independently NR1R6, NR4R5, or R4, with the proviso that at least one X must be NR1R6; each R1 is independently an optionally substituted fused bicyclic unsaturated ring containing 9 or 10 atoms optionally containing 1-4 heteroatoms selected from the group consisting of N, S and O, and the variables R2-6 are as defined in claim 1, are claimed. These compounds are kinase inhibitors useful in the treatment of cancer and viral infections.