QUINOLINE DERIVATIVES, SYNTHESIS METHOD, AND MEDICINES CONTAINING SAID DERIVATIVES

摘要

The invention concerns derivatives of formula (I), wherein: X is an alkyl-(CH2)n- chain, with n = 0, 1 or 2, or O, or N; Z is an aromatic cycle capable of comprising heteroatoms selected among O, N or S, by substitution of the carbon atoms constituting said aromatic cycle, said cycle being substituted or not by Rb; Rb represents 1 to 3 substituents selected among-OH, -OR, -COOH, -COOR, -COH, -COR, -NH2,-NH (R), -NH (R,R'), -SH, -SR and CN; Ra is H or (CH2)n'-Y, with n' = 0, 1, 2 or 3 and Y is -CH3, -COOH, -COOR, -CN, -OH, -OR, SR, or an aryl group optionally substituted by Rb; R and R' represent a linear or branched C1-C4 alkyl chain; and their pharmaceutically acceptable salts. The invention is applicable as active principle of medicines inhibiting retroviral integrases.