| 摘要 |
The invention relates to the use of multilamellar vesicles having a lamellar liquid-crystal internal structure made up of amphiphilic agent-based concentric bilayers alternated with layers of water, aqueous solution or a solution of a polar liquid, from the center to the periphery of the vesicles, and in which at least one active agent is incorporated, for producing a pharmaceutical composition for oral administration. Said vesicles act as vectors of the active agent and enable said active agent to cross the gastro-intestinal barrier more easily. The vesicles also protect the active agent from decomposition, especially decomposition by the enzymes present in the gastro-intestinal environment. The invention also relates to novel compositions for oral administration, especially compositions containing heparin, incorporated in vesicles such as those described above.
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