| 摘要 |
The invention provides isolated nucleic acids that encode GPCR-A-l, and fragments thereof, vectors for propagating and expressing GPCR-A-l nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel GPCR-A-l isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human GPCR-A-l nucleic acids, and transgenic cells and non- human organisms with targeted disruption of the endogenous orthologue of the human GPCR-A-l gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the GPCR-A-l nucleic acids, proteins, and antibodies of the present invention. |
