| 摘要 |
The invention is based in part on the discovery that nonselective kappa agonists that possess mu receptor-mediated effects in addition to their kappa agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can highly selective kappa agonists. The invention includes a number of new compounds having both nonselective kappa opioid receptor agonist activity and additional activity at mu opioid receptors. These compounds are useful for the treatment of cocaine abuse, and can also be radiolabeled for use as imaging agents, e.g., the N-fluoroalkyl and iodoalkyl derivatives can be used, respectively, for positron emission tomography (PET) and single photon computed tomography (SPECT) brain imaging.
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