Zwischenprodukte zur Herstellung von Duocarmycin SA und dessen Derivaten sowie ein Verfahren zur Herstellung der Zwischenprodukte

摘要

Indole derivatives shown by the formulae (1), (2a) and (2b) (wherein R<1> is a protecting group for amino group; R<2> is a protecting group for hydroxyl group; R<3> is a protecting group for hydroxyl group; R<4> is a C1-C6 linear or branched lower alkyl group, or benzyl group), and pyrroloindole derivatives shown by formula (3) (wherein R<1> is a protecting group for amino group; R<2> is a protecting group for hydroxyl group; R<3> is a protecting group for hydroxyl group; R<4> is a C1-C6 linear or branched lower alkyl group, or benzyl group), both of which are intermediates for duocarmycin SA, which is expected to be used as an anticancer agent, and derivatives thereof; and a method for producing the same.