COMPOSITION AND METHOD FOR TREATING GRAFT-VERSUS-HOST DISEASE

摘要

Compositions and method are provided for prevention and clinical treatment o f various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatmen t of humans in vivo as well as for ex vivo conditioning of organ transplants i n order to specifically suppress T-lymphocyte mediated immune responses while minimizing systemic toxicity of the drug.