发明名称 |
Process for the preparation of vitamin D analogues |
摘要 |
<p>A stereospecific method for accomplishing the below reaction: <CHEM> results in the compound of formula 2 having the same stereochemistry at both carbon 1 and carbon 3 as that in the compound of formula 1. Thus, if carbon 3 is in the R-configuration in the compound of formula 1, then carbon 3 will be in the R-configuration in the compound of resulting formula 2. In the above process, R<1> is C1-C6 alkyl that can be straight-chain or branched. The process functions using a fluorinated alcohol having a pKa less than about 9, in the presence of a palladium catalyst. The compounds of formula 1, as well as novel intermediates in this process, are useful in manufacturing vitamin D analogs.</p> |
申请公布号 |
EP1078931(A3) |
申请公布日期 |
2003.04.16 |
申请号 |
EP20000117261 |
申请日期 |
2000.08.16 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
DANIEWSKI, ANDRZEJ ROBERT;KABAT, MAREK MICHAL;OKABE, MASAMI;RADINOV, ROUMAN NIKOLAEV |
分类号 |
C07C401/00;C07B53/00;C07B61/00;C07C67/31;C07C67/333;C07C69/732;C07D303/32;C07D303/40;C07F7/18;(IPC1-7):C07F7/18;C07D303/12 |
主分类号 |
C07C401/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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