Dipeptidyl peptidase IV inhibitors and therapeutical preparations containing such inhibitors

摘要

Compounds according to general formula 1, wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is O, S or CH 2 , X 3 is NR 5 or a carbonyl or thiocarbonyl group and R 4 is R 6 R 7 N, R 8 (CH 2 ) q OC(=O), R 8 (CH 2 ) q OC(=S), R 6 R 7 NC(=O), R 6 R 7 NC(=S); R 8 (CH 2 ) q C(=O), R 8 (CH 2 ) q C(=S) or R 8 (CH 2 ) q SO 2 , m is 1-3 and n is 0-4 are new. The compounds of the invention are inhibitors of dipeptidyl peptidase IV. Pharmaceutical compositions of the compounds of the invention, or pharmaceutically acceptable salts thereof, are useful in the treatment of, inter alia, type 2 diabetes.