Process for preparing sterile ointment containing acyclovir

摘要

The invention refers to a process for the preparation of a sterile ointment, especially an eye ointment, containing acyclovir or a pharmaceutically suitable acid addition salt thereof as the active ingredient by homogenizing micronized acyclovir or a pharmaceutically acceptable acid addition salt thereof and the sterile carriers of the ointment in an aseptic way, then filling the homogenous ointment into sterile containers and sealing the containers. According to the process of the invention, 1 part by mass of acyclovir or a pharmaceutically suitable acid addition salt thereof consisting of particles that are lower in size than 60 mu m, preferably 20 mu m, are admixed to 1-30 parts by mass of vaseline and/or liquid paraffin and/or a mixture of solid and liquid paraffin, the mixture is hermetically sealed and kept at 120-150 DEG C for 0.3-5 hours, and the sterile mixture obtained is homogenized with a further sterile portion of the carriers in an aseptic way in a manner knows per se.