| 摘要 |
A compound of the formula (I): <CHEM> wherein R<1> is hydroxy and the like; R<2> is optionally substituted lower alkyl and the like; R<3> is hydrogen atom and the like; R<4> is optionally substituted arylene and the like; R<5> is a group represented by the formula: <CHEM> and the like; R<6> is optionally substituted aryl and the like, its optically active substance, its prodrug, their pharmaceutically acceptable salt, or solvate thereof and metalloproteinase inhibitors containing them.
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