| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing industrially useful and optically active pyrazolopyridinepyridazinone derivative and characterized by being influenced with an enzyme. SOLUTION: This production method is useful for industrial production of an optically active pyrazolopyridinepyridazinone derivative having an R- configuration or an S-configuration and represented by general formula (3) (wherein R2 is a lower alkyl; * indicates the location of an optically active asymmetric carbon atom) and characterized by acting an enzyme having asymmetric hydrolysis activity on a racemic compound of a pyrazolopyridinepyridazinone derivative, optically dividing into an optically active pyrazolopyridinepyridazinone derivative and, if necessary, removing the substituent at the site 2 of the pyridazinone ring. |
