发明名称 Structural analogues of vitamin D
摘要 A compound of the formula I:in whichP is hydrogen or alkyl;Y and Y' are each hydrogen or, when taken together, represent a group =CH2;W and W' are each hydrogen;X is selected from the group consisting of a hydroxyalkyl, a hydroxyalkoxy, an alkoxy optionally comprising an epoxide function, a hydroxyalkene, a hydroxyalkadiene, a hydroxyalkyne and isomeric forms thereof; anda) either R1 and R3 or R'3 form a saturated 5- or 6-membered carbocyclic ring and R2, R'2, R3 or R'3, R4, R'4, R5 and R'5 are each independently hydrogen or alkyl; orb) R2 or R'2 and R4 or R'4 form a saturated 5- or 6-membered carbocyclic ring, and R1, R2 or R'2, R3, R'3, R4 or R'4, R5 and R'5 are each independently hydrogen or alkyl; orc) R3 or R'3 and R5 or R'5 form a saturated or unsaturated 5- or 6-membered carbocyclic ring, and R1, R2, R'2, R3 or R'3, R4, R'4, and R5 or R'5 are each independently hydrogen or alkyl; ord) R3 or R'3 taken at the same time with R1 and R5 or R'5 form a saturated 8- or 12-membered carbobicyclic ring, and R2, R'2, R3 or R'3, R4, R'4, and R5 or R'5 are each independently hydrogen or alkyl.
申请公布号 US6548715(B1) 申请公布日期 2003.04.15
申请号 US19990428927 申请日期 1999.10.28
申请人 LABORATOIRE THERAMEX S.A. 发明人 BOUILLON ROGER;VANDEWALLE MAURITS;DE CLERCQ PIERRE JEAN
分类号 A61K31/59;A61K31/045;A61K31/075;A61P17/00;A61P19/10;A61P29/00;A61P35/00;A61P43/00;C07C35/22;C07C35/27;C07C43/188;C07C45/28;C07C47/192;C07C47/198;C07C47/347;C07C47/36;C07C47/37;C07C49/242;C07C49/517;C07C49/523;C07C49/687;C07C49/743;C07C49/755;C07C57/26;C07C59/01;C07C61/13;C07C69/18;C07C69/21;C07C69/757;C07C255/47;C07C401/00;(IPC1-7):A61K31/075 主分类号 A61K31/59
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