VERFAHREN ZU TRENNUNG VON FTC ISOMERE UND DEREN DERIVATE

摘要

The present invention relates to a method of preparing enantiomers and diastereomers of a 2',3'-dideoxy-5-fluoro-3'thiocytadine (FTC) or a derivative thereof as represented by the following structural formula:In Structural Formula I, R is H, a substituted or unsubstituted organic acid radical, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroaralkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted heterocycloalkyl group, a substituted or unsubstituted cycloalkylalkyl, a substituted or unsubstituted heterocycloalkylalkyl, a sugar or a protecting group.