AN INVERTEBRATE ANIMAL MODEL WITH ALZHEIMER-LIKE PATHOLOGY FOR SCREENING AND TESTING MOLECULES

摘要

This invention claims an invertebrate animal that has been modified to express a set of genes, said set comprising the gene coding for a vertebrate amyloid precursor protein (APP) and a gene coding for a vertebrate b-secretase (b-site APP cleaving enzyme). According to the invention, the animal displays an identifiable phenotype. This animal provides a model of neurodegenerative disease, particularly of Alzheimer s disease, and may be useful for the screening and testing of modulating agents and for the identification and validation of novel drug targets of neurodegenerative disease, in particular Alzheimer s disease.