Alpha-N-acetylgalactosaminidase from Clostridium perfringens

摘要

An isolated and purified alpha-N-acetyl-D-galactosaminidase from Clostridium perfringens and homologs thereof are disclosed. A method for purifying and isolating the alpha-N-acetylgalactosaminidase from Clostridium perfringens by removing neuramidases is disclosed. A process for using the alpha-N-acetylgalactosaminidase from Clostridium perfringens in altering type A blood cells to type O blood cells is disclosed. A process for altering cells expressing blood group A epitope by using alpha-N-acetylgalactosaminidase isolated from Clostridium perfringens in altering the cells expressing blood group A epitope to cells expressing blood group O epitope is disclosed.