Substituted indolinones, preparation thereof and their use as pharmaceutical compositions

摘要

Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumour cells, and inhibitors of protein kinases. The following compounds are exemplary:(Z)-3-{1-[4-(N-(2-aminoethyl)-N-methylsulphonyl-amino)-pheny lamino]-1-phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone, (Z)-3-{1 -[4-(N-(2-dimethylaminoethyl)-N-phenylsulphonyl-amino)-phenylamino]-1- phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone, and (Z)-3-{1-[4-(4-methylpiperazinomethyl)-phenylamino]-1-phenyl-methylide ne}-5-phenylsulphonylamino-2-indolinone