PROCESS OF PURIFICATION OF AMYLOID FIBRILS

摘要

A method of purifying amyloid fibrils comprises treating a sample containing the fibrils with a protease, detergent, chemical denaturant or chaotrope. The amyloid fibrils may then be collected from the treated sample. The treatment is preferably carried out under conditions which allow digestion, degradation or denaturation of amorphous aggregates and soluble precursors in the sample but which do not digest, degrade or denature the amyloid fibrils. A homogonous preparation of amyloid fibrils is provided in which fibrils comprise at least 80 % by weight of protein in the sample.