发明名称 PEGYLATED AND DIGLYCOSYLATED ERYTHROPOIETIN
摘要 The invention provides an erythropoietin mutein having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells, characterized by being N-glycosylated at Asn38 but not N-glycosylated at Asn24. Such muteins have improved pharmaceutical properties.
申请公布号 WO03029291(A2) 申请公布日期 2003.04.10
申请号 WO2002EP10556 申请日期 2002.09.20
申请人 F. HOFFMANN-LA ROCHE AG 发明人 TISCHER, WILHELM
分类号 C12P21/02;A61K38/00;A61K38/22;A61K47/48;A61P7/06;C07K14/505;C12N15/12 主分类号 C12P21/02
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