4-(1-PIPERIDINY)-BUTYLCARBOXAMIDE AS D3 DOPAMINE RECEPTOR SUBTYPE SELECTIVE LIGANDS

摘要

The present invention relates to new D3 dopamine receptor subtype selective ligands of Formula (I), wherein R1 and R2 represent independently a substituent selected from hydrogen, halogen, C1-6alkyl, C1-6 alkoxy, cyano, hydroxy, trifluoromethyl, C1-6alkylsulfonyloxy, trifluoromethanesulfonyloxy, optionally substituted C1-6alkanoyloxy, amino, aminoalkyl, carboxy, aminocarbonyl, N-hydroxycarbamimidoyl, carbamimidoyl, hydroxycarbamoyl, thiocarbamoyl, sulfamoyl or mono or bicyclic heterocyclic group; Y represents an oxygen atom or NH or CH2 or OCH2 group; Q represents an optionally substituted C1-6alkyl, aryl, heteroaryl, heteroaralkyl or heteroaralkenyl group, and/or geometric isomers and/or stereoisomers and/or diastereomers and/or the salts and/or hydrates and/or solvates thereof, to the process for producing the same, to pharmacological compositions containing the same and to their use in therapy and/or prevention of psychoses (e.g. schizophrenia, schizo-affective disorders, etc.), drug (e.g. alcohol, cocaine and nicotine, opioids, etc.) abuse, cognitive impairment accompanying schizophrenia, mild-to-moderate cognitive deficits, amnesia, eating disorders (e.g. bulimia nervosa, etc.), attention deficit/hyperactivity disorder in children, psychotic depression, mania, paranoid and delusional disorders, dyskinetic disorders (e.g. Parkinson's disease, neuroleptic induced parkinsonism, tardive dyskinesias) anxiety, sexual disorders, sleep disorders, emesis, aggression, autism, pain, ophthalmological diseases (e.g. glaucoma, etc.).