发明名称 |
RECEPTOR ANTAGONIST |
摘要 |
[In the formula, p is an integer of 1 to 3; R1 represents a heterocyclic group, etc.; R2 represents -N(-R4)(-R5) (wherein R4 and R5 are the same or different and each represents hydrogen, aralkyl, etc. or R4 and R5 in cooperation with the adjacent nitrogen atom form a heterocyclic group), etc.; and Q represents -N=C(-R7)- (wherein R7 represents substituted amino, etc.), etc.] An adrenergic .alpha.2C receptor antagonist which contains as an active ingredient a fused-ring pyrimidine derivative represented by the general formula (I) or a pharmacologically acceptable salt of the derivative is provided. The antagonist is useful in treatments for and/or prevention of various diseases attributable to the hyperenergia of an adrenergic .alpha.2C receptor.
|
申请公布号 |
CA2430328(A1) |
申请公布日期 |
2003.04.10 |
申请号 |
CA20022430328 |
申请日期 |
2002.09.26 |
申请人 |
KYOWA HAKKO KOGYO CO. LTD. |
发明人 |
KASHIMA, HAJIME;KANDA, TOMOYUKI;NONAKA, HIROMI;KUROKAWA, MASAKO;SHIMADA, JUNICHI;TOKI, SHINICHIRO;KUWANA, YOSHIHISA;IMMA, HIRONORI;UESAKA, NORIAKI |
分类号 |
A61K31/4196;A61K31/519;A61P3/04;A61P3/10;A61P9/12;A61P15/10;A61P25/00;A61P25/14;A61P25/16;A61P25/24;A61P43/00;C07D487/04;C07D519/00;(IPC1-7):A61K31/519;A61K45/00;C07D455/04;C07D487/14;A61K31/527;A61K31/536;A61K31/537;A61K31/538 |
主分类号 |
A61K31/4196 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|