ANTI-HIV AGENT

摘要

A polypeptide containing at least one of the following modular structures(1)to(3)and having the ability to bind to the N36 of human immunodeficiency virus;a composite thereof;and an anti−HIV agent or preventive or remedy for AIDS which contains the polypeptide or composite.(Y')m1−X1aX1b−A< sb>1−X1cX1dX1e−A2−(X")n1:modular structure 1(MS1)(Y')m2−X2a−A1A1−X2bX2c−A2A2&m inus;(X")n2:modular structure 2(MS2)(Y')m3−X3a−A1&mi nus;X3bX3cX3d−A2−X&apo s;:modular structure 3(MS3){In the modular structures,A1 represents an acidic amino acid;A2 represents a basic amino acid;X1a to X3d are the same or different and each represents any desired amino acid;X' represents any desired amino acid which may have a protective group or represents−OR1 or−NR2R3;X" represents−OR4 or−NR5R6(R1 to R6 are the same or different and each represents hydrogen,alkyl,aryl,or aralkyl);Y' represents hydrogen,R7CO−(R7 represents alkyl,optionally substituted phenyl,or optionally substituted benzyl),toluenesulfonyl,or methanesulfonyl;n1 and n2 each is 1 when MS1 and MS2 are terminated by carbon,and each is 0 when MS1 and MS2 are not terminated by carbon;m1 to m3 each is 1 when MS1,MS2,and MS3 are terminated by nitrogen,and each is 0 when MS1,MS2,and MS3 are not terminated by nitrogen;and in the modular structures(1)to(3)the amino acids each means−NH−CH(R')−CO−(R' represents a side chain of the amino acid).}