发明名称 |
Metal-carborane complexes for radioimaging and radiotherapy and methods for their preparation |
摘要 |
The present invention relates to a new method for the preparation of radiopharmaceuticals based on technetium and rhenium. The method involves the reaction of a salt of the formula [M(CO)3(X<m>)3]<(1+3m)>, wherein M is selected from a radioisotope of rhenium, technetium and any other radioisotope that binds in a similar fashion, X is any suitable ligand and m is the formal charge for ligand X, with a nido-dicarbollide dianion of the formula [nido-(C2B9H11)]<2-> and functional derivatives thereof. The method has been shown to be applicable to the preparation of radiopharmaceuticals at the tracer level.
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申请公布号 |
US2003068271(A1) |
申请公布日期 |
2003.04.10 |
申请号 |
US20020153879 |
申请日期 |
2002.05.24 |
申请人 |
VALLIANT JOHN F.;MOREL PIERRE;SCHAFFER PAUL;SOGBEIN OYEBOLA O. |
发明人 |
VALLIANT JOHN F.;MOREL PIERRE;SCHAFFER PAUL;SOGBEIN OYEBOLA O. |
分类号 |
A61K51/04;C07F13/00;(IPC1-7):A61K51/00 |
主分类号 |
A61K51/04 |
代理机构 |
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主权项 |
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地址 |
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