POLYPEPTIDES DERIVED FROM INDUCIBLE HSP70 AND PHARPOLYPEPTIDES DERIVED FROM INDUCIBLE HSP70 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME MACEUTICALCOMPOSITIONS CONTAINING THE SAME

摘要

The invention relates to a peptide comprising an amino acid sequence of at least 8 contiguous amino acids, said amino acid sequence being at least 65% identical to a portion of the same length within the amino acid sequence of inducible Hsp70, characterized in that the peptide amino acid sequence diffe rs from any amino acid sequence of the same length of the constitutive Hsc70 amino acid sequence by at least one amino acid, and that said peptide is abl e to induce in vitro or in vivo cytotoxic T lymphocytes able to specifically recognize cells naturally producing inducible Hsp70, said cytotoxic T lymphocyteS being able to recognize bath mutated and non mutated Hsp70 epitopes but not Hsc70 epitopes.