S(-)rabeprazole compositions and methods

摘要

Methods and compositions are disclosed utilizing optically pure S(-)rabeprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of rabeprazole. The optically pure S(-) isomer is also useful for the treatment of gastroesophageal reflux. S(-)rabeprazole is an inhibitor of H<+> release and is therefore useful in the treatment of other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.