| 摘要 |
<p>It is found out that a nonsteroidal antiinflammatory agent and a muscle relaxant regulate the expression of a gene carried on a viral vector. These drugs also regulate the cytotoxicity of the viral vector. Thus, a method of regulating the expression of a gene carried on a viral vector with the use of a nonsteroidal antiinflammatory agent and/or a muscle relaxant is provided. The drugs achieve reversible effects. That is, elevated gene expression from the viral vector and an increase in the cytotoxicity of the viral vector are observed after ceasing the administration of the drugs. The above drugs are useful in regulating the expression of a virus gene and a therapeutic gene in gene therapy with the use of a viral vector for gene therapy and regulating the cytotoxicity of the viral vector.</p> |
