| 摘要 |
<p>The invention concerns a 3 methylene steroid derivative having general formula (1) wherein R1 is H or together with R3 forms a bgr; epoxide or R1 is absent if there is a 5 10 or 4 5 double bond; R2 is (C1 C5)alkyl or CF3; R3 is bgr;H, bgr;CH3 or together with R1 forms a bgr; epoxide or R3 is absent if there is a 5 10 double bond; R4 is H, lower alkyl; Y is [H, H], [OH, H], =O, [OH, lower alkyl], [OH, (C2 C5)alkenyl], [OH, (C2 C5)alkynyl] or (C1 C6)alkylidene, whereby said alkyl, alkenyl, alkynyl and alkylidene is optionally halogenated; =NOR5, whereby R5 is H, lower alkyl; dotted lines represent an optional double bond, or prodrugs thereof for the treatment of arthritic diseases and or autoimmune diseases.</p> |
