METHOD OF TREATMENT USING LIGAND-IMMUNOGEN CONJUGATES

摘要

A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogeni c cells in a host animal wherein the pathogenic cells preferentially express, uniquely express or overexpress abinding site for a particular ligand. The invention comprises administering to a host animal harboring the population of pathogenic cells the ligand conjugated to an immunogen capable of activating a toll-like receptor. At least one additional therapeutic factor can be administred wherein the therapeutic factor is a compound capable of stimulating an endogenous immune response wherein the compound does not bind to the ligand-immunogen conjugate.