ISOLATED NUCLEIC ACID MOLECULES ENCODING A BACTERIAL URACIL TRANSPORT PROTEIN AND A BACTERIAL URACIL PHOSPHORIBOSYL-TRANSFERASE ENZYME, CELLS TRANSFORMED THEREWITH AND USES THEREOF

摘要

Disclosed herein are novel polynucleotides encoding one of a uracil transpor t protein and a uracil phosphoribosyl transferase, each being derived from Salmonella typhimurium. The disclosed uracil phosphoribosyl transferase protein is useful in sensitizing human cancer cells to treatment with anti- cancer agents such as 5-Fluorouracil.