ISOLATION AND PURIFICATION OF PACLITAXEL AND OTHER RELATED TAXANES WITH THE AID OF INDUSTRIAL LOW-PRESSURE PREPARATIVE CHROMATOGRAPHY ON POLYMER RESIN COLUMN

摘要

FIELD: natural compounds technology. SUBSTANCE: taxane analogues are isolated from taxane-containing sources using extraction of taxanes and separation thereof on polymer resin at low pressure involving no expensive separation/purification stages. Fractions containing taxane compounds are crystallized, mother solutions are concentrated, and polymer resins are used to isolate second taxane compound from mother solutions. EFFECT: increased yield and purity of compounds. 20 cl, 4 ex